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In veterinary off-label use, most dogs seem to respond well to it when appropriately dosed and monitored

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An animal study showed that atomoxetine increased histamine levels (in the brain).[ref] Epigenetic changes and POTS: Research points towards epigenetic modification of the SLC6A2 gene as a cause of POTS

Half-life About 159 to 195 hours (~7 to 8 days), which is why it is dosed weekly