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In the Phase III TRANSCEND-T2D-1 trial, the drug reduced HbA1c by up to 2.0% and delivered ~16.8% weight loss at 40 weeks, with no plateau observed

Primers (Integrated DNA technologies, Singapore) used for PCR reactions were listed in Table 1

As semaglutide use expands, clinicians should be vigilant for structural pancreatic changes, and further studies are warranted to elucidate underlying mechanisms and clinical implications