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186 Although results were mixed regarding an increased efficacy of combined treatment, there were some indications that tumor-associated pain could be reduced, possibly due to insulins anti-inflammatory action

Sumi D, Ignarro LJ

Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewings sarcoma cells

Maintaining a high ratio of GSH to its oxidized form GSSG, utilizing NADPH conversion to NADP, is the principal mechanism for protecting RBCs from ROS generated from the release of oxygen