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Call your doctor if you develop any unusual changes in mood and behavior or have thoughts of harming yourself while taking semaglutide

6.3 Neuropsychiatric dysfunction Obesity is associated with an increased risk of neuropsychiatric disorders, including mood disorders, schizophrenia, major neurocognitive disorder or cognitive impairment, and neurodegenerative diseases (NDDs) (183185)

Include strength training 2 to 4 times per week

Certain psychiatric medications , including some antipsychotics (olanzapine, clozapine) and mood stabilisers (lithium, valproate), can promote weight gain through mechanisms including increased appetite, insulin resistance, and reduced physical activity