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Although AAVs have traditionally been the main vector used to deliver CRISPR-Cas9 constructs, the relatively small packaging size (~4.5 kb) makes it so that researchers must deliver two separate vectors containing the CRISPR-Cas9 construct (~4.2 kb) and gRNA separately

Treatment decisions are made only by licensed medical providers based on an individual patients health history, current medications, treatment goals, and clinical review

Most CQDs are rapidly cleared renally, limiting long-term retention, although doped or larger particles may persist in liver, spleen, or tumour tissue [161, 166]