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They assist in reestablishing immune homeostasis in the reproductive tract by promoting a shift in macrophage and T-cell phenotypes toward regulatory, which supports tolerance during implantation and avoids immune-mediated gamete injury

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Those of ordinary skill in the art are able to determine the mucoadhesive characteristics of the compositions provided herein, and thus determine appropriate ranges

In humans, kavain undergoes extensive hepatic metabolism, primarily via cytochrome P450 (CYP) enzyme-mediated pathways, followed by further phase II biotransformation processes such as sulfonation, glucuronidation, and glutathione (GSH) conjugation