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Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group
Potential Anti-Aging Effects Nicotinamide N-methyltransferase (NNMT) plays a role in cellular aging, and inhibiting it may support longevity
found that female GH-deficient mice injected twice daily with 250 g/kg ipamorelin for 9 weeks increased by 15.3% while non-GH-deficient mice increased by 16.9%
Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]
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