Patients should seek immediate medical attention for concerning symptoms including: Severe persistent abdominal pain (possible pancreatitis) Right upper quadrant pain, fever, or jaundice (possible gallbladder disease) Reduced urine output or dizziness (possible acute kidney injury/dehydration) New neck mass, difficulty swallowing, or persistent hoarseness (possible thyroid tumor) There is no evidence that Zepbound causes or worsens acne vulgaris
Late complications include atrophy, flattening of the epidermis, fibrosis, telangiectasis, pigmentary changes (hyperpigmentation or hypopigmentation), and an increased risk of squamous cell carcinoma
Injecting medication from a compromised cartridge can lead to localized abscesses, cellulitis, or systemic bacterial entry
However, four fusions with a single point mutation (G2V, E15A, V19A and L26I) had potency at human GLP-1R similar to the target value and were investigated further for in vivo peptide stability and manufacturability
