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The group can be further subdivided in SOX9 + LGR5 + cells (expressing MMP7 , ESR1 , KRT17 , WNT7A ), proliferative SOX9 + cells (expressing MKI67) containing both LGR5 + and LGR5 cells, and SOX9 + CDH2 + LGR5 cells (expressing AXIN2 , ALDH1A1 , IHH ) [1]