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doi: 10.1016/j.phymed.2025.156519 91 ZhaoXTangZYueCTanZHuangB

However, it is unclear whether HDAC3-induced SOD increases are a direct effect of HDAC3 activity or the result of inflammatory inhibition, which requires further research to investigate this (Figure 4)

--- Step 3: The Dosing Simple, Standard Boluses Two-step, easy-to-remember dosing: First Dose (Loading): 300 mg IV/IO bolus Give after the 3rd shock Second Dose (Repeat): 150 mg IV/IO bolus Give if rhythm persists, after the 5th shock --- Step 4: Post-Resuscitation The Infusion If ROSC is achieved but ventricular arrhythmias persist or recur: Maintenance Infusion: 1 mg/min for 6 hours then 0.5 mg/min for the next 18 hours (total 24-hour infusion period) --- Safety Check Monitor closely for: Hypotension ( blood pressure) Bradycardia (slow heart rate) If the patient has a pulse, administer the bolus slowly over 10 minutes to minimize these side effects

The last term is the activation of CBS by oxidative stress [25, 26], which is represented by the concentration of H 2 O 2