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This is a marked improvement over oral obesity treatments, which suffer from low absorption rates of about 1% bioavailability and often cause unpleasant side effects such as vomiting, nausea, and diarrhea

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Mendelian randomization studies have identified a causal relationship between increased body mass index (BMI) and heightened kidney disease risk, with each standard deviation increase in BMI nearly doubling disease probability (odds ratio: 2.00) (155)