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reported that the stable expression of the GCGR in human embryonic kidney 293 cells led to similar increases in cAMP and intracellular Ca 2+ levels in response to glucagon treatment, and dose-dependent activation of ERK1/2 (30), highlighting the GCGR-dependent nature of the effect

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increase of dopamine in the basal ganglia and neocortices

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It has also been shown to improve cognitive function in animal models of Alzheimers disease

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