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A 2025 study reported that 22% of GLP-1 RA users were diagnosed with at least one new nutrient deficiency by the 12-month mark, and another analysis found significant declines in the intake of multiple key nutrients especially iron, magnesium, calcium, potassium, vitamins A, C, D, E, K, and B12

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Blonde, L., Umpierrez, G

Thus, in these patients, osmolarity should be monitored regularly during HD, and the dialysate formula should be modified to minimize or avoid any rapid shifts in osmolarity 47