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POMC-derived peptides, particularly -MSH, stimulate MC1R of melanocytes, releasing the intracellular second messenger cAMP, which in turn induces a cascade of intracellular molecular events, ultimately activating the microphthalmia-associated transcription factor (MITF)

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Endocrine Dysregulation in Obesity Unlike acute malnutrition, children with obesity generally exhibit normal, moderately [61] or abnormally [62] elevated serum TSH concentrations compared with their normal-weight counterparts