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Nucleic Acids Res 48 , 28532865 (2020)

Protective effect of berberine on cyclophosphamideinduced haemorrhagic cystitis in rats

However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig