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Chronic hyperglycemia has been shown to lead to lymphatic dysfunction, and insulin resistance may be a risk factor for developing lymphedema ( In addition to weight loss and glucose control, GLP-1 RAs affect both immunologic and inflammatory pathways which may have a direct and positive effect on lymphatic function ( + T cells and differentiation into T-helper 2 (Th2) cells are at the front end of this process ( + lymphocytes ( + T cells, as well as a reduction in the release of IL-5 and IL-13 ( Safety is always of utmost concernan important area of ongoing research is determining the effect of GLP-1 RAs on cancer risk and recurrence

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Many women blame the GLP-1 for sudden exhaustion when perimenopause is quietly doing half the damage