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Research has shown that signal transduction involving brain-derived neurotrophic factor (BDNF) plays a crucial role in synaptic plasticity in depression, and the downregulation of BDNF may contribute to neurotoxic effects (SHKUNDIN and HALARIS, 2023)

The authors reported improved Morris water maze performance (reduced escape latency over the training days), increased synaptophysin (a synaptic-density marker), and lower IL-1 and TNF-, with effects attributed to PI3K/AKT signaling

The beneficial effect of BPC 157 on Parkinson's disease in rats

KPV quiets the inflammatory environment so BPC-157's repair mechanisms can proceed unimpeded