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4 Tendon scar healing Following a tendon injury, the healing process unfolds through three overlapping phases: (1) the inflammatory phase, (2) the proliferative phase, and (3) the remodeling phase ( 5 The expression profile of IGF-1 in tendon healing A controlled delivery strategy for IGF-1, which accounts for the spatiotemporal complexity of the injury microenvironment and synergizes with endogenous IGF-1 production through feedback mechanisms, holds significant promise for enhancing IGF-1 therapy (Prabhath et al., 2018)