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Over time, this impingement can weaken the ACL fibers, making them more susceptible to microtears and eventual rupture
However, excessive mechanical stress and impingement can upregulate MMP expression, leading to increased collagen degradation and weakening of the ACL
A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases
Adding nutritional supplements may alter the effect of medication
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