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Some common physical and emotional symptoms that might ring a bell from puberty: irritability, weight gain, acne, mood changes and a general malaise, aka the blahs. Research has explored the more serious parallels, emphasizing how hormone fluctuations during these two periods can lead to development of depression and anxiety, metabolic and cardiovascular risks, and autoimmune conditions. Heres the major difference: During puberty, the entire world recognizes what youre going through, and biology class explains the physiology behind it