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(7) Complex II: Complex II (succinate dehydrogenase, SDH) is an FAD-dependent enzyme embedded in the mitochondrial inner membrane that oxidizes succinate to fumarate as part of the TCA cycle while transferring the resulting electrons through FAD and a series of ironsulfur clusters to ubiquinone (CoQ 10 ), reducing it to ubiquinol (CoQ 10 H 2 ) 74

Similarly, soluble CD14 (sCD14) can also bind LPS in the systemic circulation and is also used as a proxy readout of LPS-activity, although they are not always correlated (61)

When listed on the national health insurance, clear reimbursement criteria are established, making it easier for medical professionals to prescribe and oversee their use

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