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Among individuals with obesity who received fixed doses of the drug without dose escalation, 12% to 27% discontinued the treatment early due to gastrointestinal side effects

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Only five NEN types stained positively for GLP-1R, including 45% of duodenal NETs (dNETs), 17% of gastric NETs (gNETs), 13% of pancreatic NETs (pNETs), 9% of pheochromocytomas, and 2% of lung NETs (Table 1)

Slower titration is worth considering if: Nausea persists beyond 2 weeks at your current dose You experience significant GI symptoms that interfere with daily function Your body aches or muscle pain are severe You are losing weight faster than 1 to 2 percent of body weight per week (too-rapid weight loss increases muscle loss risk) Some researchers use a 6 or 8-week interval between dose increases instead of the standard 4 weeks